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The cytochrome P450 2E1 enzyme and cyclooxygenase enzymes (COX-1 and -2) metabolize exogenous and endogenous compounds that contribute to the pathogenesis of hepatotoxicity. The goal of this study was to assess the effects of COX-2 inhibitors on the bioactivation of cholestatic bile acids in a bile duct-cannulated rat model. Cholestatic rats received intraperitoneal injections of 1-5 mg of celecoxib or vehicle daily for 14 days. Intravenous injections of 3 mg of ursodeoxycholic acid or vehicle were administered 1 hr after the celecoxib or vehicle be359ba680
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